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apalutamide will minimize the level or influence of diazepam by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Coadministration of apalutamide, a strong CYP3A4 inducer, with medicines which are CYP3A4 substrates can lead to decrease exposure to these drugs.It really works while in the central nervous method and